A low-cost and facile electrochemical sensor for the trace-level recognition of flutamide in biofluids using large-area bimetallic NiCo2O4 micro flowers

Durai, Lignesh and Gopalakrishnan, Arthi and Badhulika, Sushmee (2022) A low-cost and facile electrochemical sensor for the trace-level recognition of flutamide in biofluids using large-area bimetallic NiCo2O4 micro flowers. New Journal of Chemistry, 46 (7). pp. 3383-3391. ISSN 1144-0546

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Abstract

In this work, we demonstrate a simplistic, substrate-free hydrothermal synthesis of the nickel-cobalt-based bimetallic oxide compound (NiCo2O4) as a highly sensitive and selective platform for the detection of flutamide in biological fluids. The NCO/GCE sensor shows a low detection limit (LOD) of 4 nM (LOD = 3s/m). The sensor shows two linear ranges of detection, namely nanomolar (10-500 nM) and micromolar (1-400 μM) with a sensitivity of 120.17 μA μM−1 cm−2 and 23.18 μA μM−1 cm−2, respectively. The enhanced sensing performance of the sensor is attributed to the electro-catalytic active sites of the NOC micro flowers facilitated with the Ni2+/Ni3+ and Co2+/Co3+ redox couple. The sensor is efficacious in the detection of flutamide in simulated blood serum with a decent range of recovery percentages from ∼106.45 to ∼97.60%. The efficacy of the NCO/GCE sensor using a facile, low-cost method prompts its versatile use as a promising platform for bioanalytical applications. This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique

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IITH Creators:

IITH Creators	ORCiD
Badhulika, Sushmee	https://orcid.org/0000-0003-3237-3031

Item Type:

Article

Additional Information:

SB acknowledges financial assistance from IIT Hyderabad Rural Development Program project no. RURDEV/2021/F135/ RD02. LD acknowledges the SEM characterization facility funded by DST-FIST project No. DST-FIST (SR/FST/ETI-421/ 2016).

Uncontrolled Keywords:

Bimetallic oxides; Bimetallics; Biofluids; Biological fluids; Cobalt-based; Low detection limit; Low-costs; Oxide compounds; Substrate-free; Trace level

Subjects:

Electrical Engineering

Divisions:

Department of Electrical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

18 Jul 2022 11:08

Last Modified:

18 Jul 2022 11:08

URI:

http://raiithold.iith.ac.in/id/eprint/9639