Doxorubicin loaded polyvinylpyrrolidone-copper sulfide nanoparticles enabling mucoadhesiveness and chemo-photothermal synergism for effective killing of breast cancer cells

R, Gayathri and S, Rajalakshmi P and Thomas, Aswathi and Rengan, Aravind Kumar (2021) Doxorubicin loaded polyvinylpyrrolidone-copper sulfide nanoparticles enabling mucoadhesiveness and chemo-photothermal synergism for effective killing of breast cancer cells. Materialia. p. 101195. ISSN 25891529

Full text not available from this repository. (Request a copy)

Abstract

The synergistic effect of chemo-photothermal therapy by near-infrared light-responsive nanoparticles is being widely researched. The combination of chemo-photothermal effects reduces the regrowth of tumor residuals by enhancing therapeutic coverage when compared with a single treatment modality. In the current study, doxorubicin hydrochloride-loaded polyvinylpyrrolidone-copper sulfide nanoparticles (DP-CuS NPs) were synthesized by a facile one-pot method. DP-CuS NPs showed good muco-adherence and also acted as an efficient chemo-photothermal agent. The polyvinylpyrrolidone (PVP) coating prevented the aggregation of CuS NPs and helped in stabilizing the size (hydrodynamic diameter ̴35nm) of the synthesized nanoparticle. PVP also served as a cargo, enabling the loading of a chemotherapeutic drug (doxorubicin) with an efficiency of ̴75 %. The localized release of doxorubicin was achieved by photothermal/pH trigger upon DP-CuS NPs, enhancing therapeutic efficiency. DP-CuS NPs, when treated with breast cancer cell line (MCF 7), exhibited efficient cancer cell cytotoxicity (cell viability: ̴11 %) and photothermal triggered mucolytic properties. These nanoparticles were also effective in preventing the growth of residual cancer cells through their mucolytic property and chemo-photothermal dual therapeutic effect.

[error in script]

IITH Creators:

IITH Creators	ORCiD
R, Gayathri	UNSPECIFIED
S, Rajalakshmi P	UNSPECIFIED
Thomas, Aswathi	UNSPECIFIED
Rengan, Aravind Kumar	UNSPECIFIED

Item Type:

Article

Uncontrolled Keywords:

Breast cancer cells; Chemo-photothermal therapy; Copper sulphide nanoparticle; Copper sulphides; Doxorubicin; Mucoadhesive properties; Photo-thermal; Polyvinyl pyrrolidone; Synthesised; Triggered drug release;Cell culture; Cells; Controlled drug delivery; Copper compounds; Diseases; Efficiency; Infrared devices; Nanoparticles; Synthesis (chemical); Targeted drug delivery

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

30 Aug 2021 07:27

Last Modified:

30 Aug 2021 07:27

URI:

http://raiithold.iith.ac.in/id/eprint/8802