Regioselective C3–H Trifluoromethylation of 2H-Indazole under Transition-Metal-Free Photoredox Catalysis

Murugan, Arumugavel and Babu, Venkata Nagarjuna and Sharada, D S and et al, . (2019) Regioselective C3–H Trifluoromethylation of 2H-Indazole under Transition-Metal-Free Photoredox Catalysis. The Journal of Organic Chemistry, 84 (12). pp. 7796-7803. ISSN 0022-3263

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Abstract

Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a visible-light-promoted regioselective C3-H trifluoromethylation of 2H-indazole under metal-free conditions, which proceeds via a radical mechanism. The combination of photocatalysis and hypervalent iodine reagent provides a practical approach to a library of trifluoromethylated indazoles in 35-83% yields.

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IITH Creators:	IITH Creators ORCiD Sharada, D S UNSPECIFIED
Item Type:	Article
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	08 Jul 2019 06:06
Last Modified:	08 Jul 2019 06:06
URI:	http://raiithold.iith.ac.in/id/eprint/5648
Publisher URL:	http://doi.org/10.1021/acs.joc.9b00676
Related URLs:	Google Scholar

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