SYNTHESIS OF TERT-BUTYL (2-((2-(2,4-DIOXO-3,4 DIHYDROBENZO[G]PTERIDIN-10(2H)-YL)ETHYL)AMINO)-2-OXOETHYL)CARBAMATE

Kayal, Swatilekha and Mishra, Ashutosh Kumar (2019) SYNTHESIS OF TERT-BUTYL (2-((2-(2,4-DIOXO-3,4 DIHYDROBENZO[G]PTERIDIN-10(2H)-YL)ETHYL)AMINO)-2-OXOETHYL)CARBAMATE. Masters thesis, Indian institute of technology Hyderabad.

Text
Msc_Thesis_TD1337_2019.pdf
Restricted to Repository staff only until 17 May 2024.
Download (2MB) | Request a copy

Abstract

Impetus to design and investigate the biomimetic model systems are primarily driven to have an in-depth insight into the natural phenomenon, in lieu of fine tuning the key structural aspects to achieve better control over the functional aspect of the biomolecule in consideration. In this context we are interested in understanding the structural and functional implications of the “covalently linked Flavin cofactors” within the protein matrix. The lure of biomimetic approach to have an insight into the significance of covalent flavinylation and to modulate the inherent properties for the desired purpose, has prompted us to synthesize and characterize tert- butyl (2-((2-(2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethyl)amino)-2-oxoethyl)carbamate (FL-GY). Two different synthetic routes have been tried and tested with 52% overall yield.

[error in script]

IITH Creators: