Nanostructured Metal Oxide-Based Microfluidic Biosensors for Point-of-Care Diagnostics

Md, Azahar Ali (2014) Nanostructured Metal Oxide-Based Microfluidic Biosensors for Point-of-Care Diagnostics. PhD thesis, IIT Hyderabad.

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Abstract

The potential research on microfluidic devices for detection of biomolecules has recently intensified due to its application in point-of-care (POC) diagnostics for global health care. Early detection plays an imperative role to determine predisposition to disease (prevention) or the outcome of disease (monitoring and prognosis). There is a significant need for POC diagnostics devices as perceived from biohazard threats, the spread of infectious disease, home testing and monitoring. The POC diagnostics can provide a convenient and immediate response to a patient test sample. The POC diagnostics can be attained via use of transportable, portable, and handheld instruments such as blood glucometer, cholesterol meter etc. and test kits. It includes testing of blood or urine for pathogens, glucose, cholesterol, blood gas, coagulation, biomarkers, hemoglobin, pregnancy etc. Cheaper, smaller, faster, and smarter devices are the main merits of POC diagnostics for detection of various target analytes. A number of clinical biochemical studies such as blood gas, glucose/lactate/cholesterol, nucleic acid sequence analysis, proteins/peptides, combinatorial synthesis, toxicity monitoring, immunoassays, and forensic analysis are also focused areas for developing microfluidic biochips.

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