Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers

Adepu, S and Gaydhane, M K and Kakunuri, M and Sharma, Chandra Shekhar and Khandelwal, Mudrika and Eichhorn, S J (2017) Effect of micropatterning induced surface hydrophobicity on drug release from electrospun cellulose acetate nanofibers. Applied Surface Science. ISSN 0169-4332 (In Press)

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Abstract

Sustained release and prevention of burst release for low half-life drugs like Diclofenac sodium is crucial to prevent drug related toxicity. Electrospun nanofibers have emerged recently as potential carrier materials for controlled and sustained drug release. Here, we present a facile method to prevent burst release by tuning the surface wettability through template assisted micropatterning of drug loaded electrospun cellulose acetate (CA) nanofibers. A known amount of drug (Diclofenac sodium) was first mixed with CA and then electrospun in the form of a nanofabric. This as-spun network was hydrophilic in nature. However, when electrospinning was carried out through non-conducting templates, viz nylon mesh with 50 and 100 μm size openings, two kinds of hydrophobic micro-patterned CA nanofabrics were produced. In vitro transdermal testing of our nanofibrous mats was carried out; these tests were able to show that it would be possible to create a patch for transdermal drug release. Further our results show that with optimized micro-patterned dimensions, a zero order sustained drug release of up to 12 h may be achieved for the transdermal system when compared to non-patterned samples. This patterning caused a change in the surface wettability, to a hydrophobic surface, resulting in a controlled diffusion of the hydrophilic drug. Patterning assisted in controlling the initial burst release, which is a significant finding especially for low half-life drugs.

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IITH Creators:

IITH Creators	ORCiD
Sharma, Chandra Shekhar	UNSPECIFIED
Khandelwal, Mudrika	UNSPECIFIED

Item Type:

Article

Additional Information:

Authors acknowledge the Indian Institute of Technology, Hyderabad for providing necessary research infrastructure to carry out this work. The authors also acknowledge Dr. Balaji Padya, Centre for Carbon Materials, ARCI for his help to perform DSC analysis. CSS acknowledges DST INSPIRE Faculty award research grant for electrospinning facility.

Uncontrolled Keywords:

Drug release, electrospinning, nanofibers, micro-patterning, diclofenac sodium

Subjects:

Materials Engineering > Materials engineering
Chemical Engineering

Divisions:

Department of Chemical Engineering
Department of Material Science Engineering

Depositing User:

Team Library

Date Deposited:

07 Aug 2017 09:56

Last Modified:

20 Sep 2017 11:19