Electrospun gelatin nanofibers as drug carrier: effect of crosslinking on sustained release

Laha, A and Sharma, Chandra Shekhar and Majumdar, Saptarshi (2016) Electrospun gelatin nanofibers as drug carrier: effect of crosslinking on sustained release. Materials Today: Proceedings, 3 (10). pp. 3484-3491. ISSN 2214-7853

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Abstract

This study aims to develop a natural biopolymer based nanofabric as an oral drug carrier to deliver a model hydrophobic drug (piperine) in a sustained and controlled manner over prolonged time. For that, we electrospun gelatin nanofabric mesh followed by crosslinking using saturated vapor of glutaraldehyde (GTA) for 8 mins to improve the water resistive properties. Later, we investigated the effect of different crosslinking strategies and found that layer-by-layer crosslinking not only provides an improved structural integrity, thermal and chemical stability of drug but also yields a tight control over sustained drug release up to 8 h.

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IITH Creators:	IITH Creators ORCiD Sharma, Chandra Shekhar UNSPECIFIED Majumdar, Saptarshi UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	Gelatin nanofiber; Drug delivery; Hydrophobic drug; Crosslinking; Glutaraldehyde vapor
Subjects:	Chemical Engineering > Biochemical Engineering
Divisions:	Department of Chemical Engineering
Depositing User:	Team Library
Date Deposited:	13 Dec 2016 04:43
Last Modified:	17 Oct 2017 09:52
URI:	http://raiithold.iith.ac.in/id/eprint/2929
Publisher URL:	https://doi.org/10.1016/j.matpr.2016.10.031
OA policy:	http://www.sherpa.ac.uk/romeo/issn/2214-7853/
Related URLs:	Google Scholar

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