Dnyandev, Phad Vaibhav
(2016)
Full - Field Optical Coherence Tomography and Monte Carlo Simulations for Biological Tissues.
Masters thesis, Indian Institute of Technology Hyderabad.
Abstract
Optical
Coheren
ce
Tomography (
OCT) is
a
n emerging
imaging technique
that has
been successfully demonstrated
for non
-
invasive, non
-
contact and
in
-
vivo
imaging of biological specimen.
Over the years, several OCT
modifications have been developing so that present
OCT
system
limitations
can be overcome thereby
extending its applications in various fields.
Full
-
field OCT (FF
-
OCT) is one of the recent advancement in the OCT. In this
thesis,
FF
-
OCT
system for imaging of biological tissues is presented. The
image reconstr
uction of the system is performed using phase stepping
methods to produce object images with better computational efficiency. This
thesis also explores Monte Carlo met
hod
for mathematical modeling of
light
-
tissue
interaction
.
Monte Carlo is the statistical
analysis of random sampling
from the probability distributions
used
for tracking the photon movements
inside the biological tissues. Various tissue models
are created
,
and its
fluence rates are analyzed
.
Furthermore, Monte Carlo method
is developed
for sa
mpling and modeling of Gaussian beam on the
multi
-
layered
tissue.
The absorption and fluence spectra
have been
analyzed
for different types of
Gaussian beam. Finally, comparison of beam profiles at different beam
radius has been
done
.
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