CFD Simulation as an alternate diagnostic tool for a blocked artery

Manohar, Sabbani (2016) CFD Simulation as an alternate diagnostic tool for a blocked artery. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Narrowing or blockage in the coronary arteries supplying blood to the heart muscle manifest as symptoms like chest discomfort or pain and shortness of breath. Symptomatic patients are screened for blocked arteries using coronary angiograms. However, an angiogram provides approximate degree of obstruction. Further, we need to check the significance of obstruction to decide the need for intervention. Interventions like stenting or surgery will depend upon the degree of obstruction and functional impairment.This is evaluated by procedures like measurement of Fractional Flow Reserve (FFR).FFR is the ratio of pressure distal to the stenosis to the pressure proximal to the stenosis.FFR is measured using a specialized probe inserted through a catheter tube, and the technique is expensive.In this study, we propose a workflow to calculate FFR in a non-invasive manner using CFD simulations, and validate it by comparing the results with data from patients.

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