Palladium-Catalyzed Domino Process: Synthesis of Symmetrical Diarylalkynes, cis- and trans-Alkenes using Lithium Acetylide as a Synthon

J, Krishna and A G, Krishna Reddy and G, Satyanarayana (2015) Palladium-Catalyzed Domino Process: Synthesis of Symmetrical Diarylalkynes, cis- and trans-Alkenes using Lithium Acetylide as a Synthon. Advanced Synthesis and Catalysis. ISSN 1615-4150 (In Press)

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Abstract

An efficient domino protocol has been developed for the synthesis of symmetrical diarylalkynes. Notably, the method was successful in the presence of a palladium catalyst without the support of a copper co-catalyst. Significantly, the method enabled the use of the commercially available and cheap lithium acetylide ethylenediamine complex as a source of acetylene for the construction of dual C[BOND]C bonds, with a wide range of compatibility towards various substituents of the aryl bromides/iodides. Significantly, this protocol was successfully applied to the synthesis of cis- and trans-alkenes in a highly stereoselective manner in a sequential one-pot process.

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IITH Creators:	IITH Creators ORCiD G, Satyanarayana UNSPECIFIED
Item Type:	Article
Additional Information:	Supporting Information: http://onlinelibrary.wiley.com/doi/10.1002/adsc.201500686/suppinfo
Uncontrolled Keywords:	cis-alkenes;trans-alkenes;diarylalkynes;domino reactions;Sonogashira coupling
Subjects:	Chemistry > Organic chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	03 Nov 2015 05:30
Last Modified:	03 Nov 2015 05:30
URI:	http://raiithold.iith.ac.in/id/eprint/2009
Publisher URL:	http://dx.doi.org/10.1002/adsc.201500686
OA policy:	http://www.sherpa.ac.uk/romeo/issn/1615-4150/
Related URLs:	Google Scholar

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