Enantioselective syntheses of bicyclic lactams based on iridium-catalyzed asymmetric allylic substitution and heck cyclization

G, Satyanarayana and Helmchen, G (2014) Enantioselective syntheses of bicyclic lactams based on iridium-catalyzed asymmetric allylic substitution and heck cyclization. European Journal of Organic Chemistry, 2014 (11). pp. 2242-2252. ISSN 1434-193X

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Abstract

A sequence of reactions that include an iridium-catalyzed regio- and enantioselective allylic amination, the formation of an amide, a ruthenium-catalyzed ring-closing metathesis, and an intramolecular Heck reaction allows for the preparation of [3,3,1]- and [4,3,1]-bicyclic amides. The target compounds have a nitrogen atom at the bridgehead, a nonplanar amide moiety, and a stereogenic center at the one-carbon bridge

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IITH Creators:	IITH Creators ORCiD G, Satyanarayana UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	Asymmetric catalysis; Cyclization; Enantioselectivity; Iridium; Lactams; Palladium; Synthetic methods
Subjects:	?? sub5.8 ??
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	17 Dec 2014 04:17
Last Modified:	24 Sep 2015 10:03
URI:	http://raiithold.iith.ac.in/id/eprint/1162
Publisher URL:	http://dx.doi.org/10.1002/ejoc.201301813
Related URLs:	Google Scholar

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