The Promises of Proteomics and Metabolomics for Unravelling the Mechanism and Side Effect Landscape of Beta-Adrenoceptor Antagonists in Cardiovascular Therapeutics

Ray, Sandipan (2023) The Promises of Proteomics and Metabolomics for Unravelling the Mechanism and Side Effect Landscape of Beta-Adrenoceptor Antagonists in Cardiovascular Therapeutics. OMICS A Journal of Integrative Biology, 27 (3). pp. 87-92. ISSN 1536-2310

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Abstract

Cardiovascular medicine witnessed notable advances for the past decade. Multiomics research offers a new lens for precision/personalized medicine for existing and emerging drugs used in the cardiovascular clinic. Beta-blockers are vital in treating hypertension and chronic heart failure. However, clinical use of beta-blockers is also associated with side effects and person-to-person variations in their pharmacokinetics and pharmacodynamics. A comprehensive understanding of the mechanisms that underpin the side effect landscape of beta-blockers is imperative to optimize their therapeutic value. In addition, current research emphasizes the circadian clock's vital roles in regulating pharmacological parameters. Administration of the beta-blockers at specific dosing times could potentially improve their effectiveness and reduce their toxic effects. The rapid development of mass spectrometry technologies with chemical proteomics and thermal proteome profiling methods has also substantially advanced our understanding of underlying side effects mechanisms by unbiased deconvolution of drug targets and off-targets. Metabolomics is steadily demonstrating its utility for conducting mechanistic and toxicological analyses of pharmacological compounds. This article discusses the promises of cutting-edge proteomics and metabolomics approaches to investigate the molecular targets, mechanism of action, adverse effects, and dosing time dependency of beta-blockers.

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IITH Creators:

IITH Creators	ORCiD
Ray, Sandipan	http://www.orcid.org/0000-0002-9960-5768

Item Type:

Article

Uncontrolled Keywords:

beta-adrenoceptor antagonists; cardiovascular diseases; chronomedicine; drug toxicity and side effects; metabolomics; proteomics; beta adrenergic receptor blocking agent; beta adrenergic receptor blocking agent; Adrenergic beta-Antagonists; Drug Delivery Systems; Humans; Hypertension; Metabolomics; Proteomics; adverse event; cardiovascular disease; circadian rhythm; human; metabolomics; molecular clock; nonhuman; proteomics; Review; unspecified side effect; drug delivery system; hypertension; metabolomics; procedures

Subjects:

Others > Biotechnology

Divisions:

Department of Biotechnology

Depositing User:

Mr Nigam Prasad Bisoyi

Date Deposited:

24 Aug 2023 11:14

Last Modified:

24 Aug 2023 11:14

URI:

http://raiithold.iith.ac.in/id/eprint/11616