Paul, Nilanjan and Patra, Tuhin and Maiti, Debabrata
(2022)
Recent Developments in Hydrodecyanation and Decyanative Functionalization Reactions.
John Wiley and Sons Inc.
Full text not available from this repository.
(
Request a copy)
Abstract
Nitrile is one of the ubiquitous functional groups in natural products and polymer industry. It is often used as a versatile building block in synthetic chemistry. Classically, nitrile group is used for alpha functionalization, ortho−C−H activation and as a precursor for amine or carbonyl functionalities. With the development of various transition metal catalyzed methods, in the last two decades, nitrile group has emerged as a source of carbon synthons through C−CN bond activation despite of its high bond energy. In this review we have summarized all recent developments involving the carbon synthons arising from the cleavage of C−CN bonds. Depending on the fate of the carbon center after cleavage, all the reactions are classified in two major categories for the ease of discussion: 1) decyanation (removal of the nitrile group) and 2) decyanative functionalization (replacement of the nitrile group). Finally, current limitations in C−CN bond activation strategies and future prospects are discussed. © 2021 Wiley-VCH GmbH
Actions (login required)
 |
View Item |
Altmetric
Altmetric