Multifunctional Polymeric Nanoparticles for Chemo/Phototheranostics of Retinoblastoma

Mudigunda, Sushma Venkata and Pemmaraju, Deepak B. and Rengan, Aravind Kumar and et al, . (2022) Multifunctional Polymeric Nanoparticles for Chemo/Phototheranostics of Retinoblastoma. ACS Biomaterials Science & Engineering, 8 (1). pp. 151-160. ISSN 2373-9878

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Abstract

Retinoblastoma (Rb) is the most critical and severe intraocular malignancy occurring in children. The clinical management of retinoblastoma is still challenging due to failure in early detection and control despite the advancements in medical strategies. Early-stage Rb tumors do not occupy major visual fields, so chemo/photothermal therapy (PTT) with biocompatible materials can be a practical approach. Herein, we report multifunctional polymeric nanoparticles (PNPs) entrapped with an FDA-approved anticancer drug, Palbociclib (PCB), and a near-infrared dye, IR820 (IR), as chemo/photothermal agents. These PCB/IR PNPs were evaluated for the combinational effect in the retinoblastoma cell line. Further, the in vivo photoacoustic imaging efficacy and acute toxicity profile of the PNPs were studied in a mice model. The results indicated that the PCB/IR PNPs exhibited a significant cytotoxic effect (86.5 ± 2.3%) in Y79 cell lines than the respective control groups upon exposure to NIR light. Qualitative and quantitative analyses indicated that PCB/IR PNPs with NIR light induction resulted in DNA damage followed by apoptosis. PCB/IR PNPs, when tested in vivo, showed optimal photoacoustic signals. Thus, the combination of PCB and PTT can emerge as a translational modality for retinoblastoma therapy. © 2021 American Chemical Society.

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IITH Creators:

IITH Creators	ORCiD
Rengan, Aravind Kumar	https://orcid.org/0000-0003-3994-6760

Item Type:

Article

Additional Information:

S.V.M. would like to acknowledge the MHRD for the fellowship. The authors acknowledge the Govt. of India for funding of the following projects: DBT NNT (BT / NNT / 28 / 1386 / 2017), MHRD IMPRINT (4291), DST Inspire (DST/INSPIRE/04/2015/000377), and CRG DST-AMT (DST/TDT/AMT/2017/227(G)). The authors also acknowledge Vasudha foundations, Hyderabad, for their generous financial support.

Uncontrolled Keywords:

Clinical management; Detection and controls; In-vivo; Intraocular; Medical strategy; Multi-functional nanoparticles; NIR dyes; Photothermal therapy; Polymeric nanoparticles; Retinoblastoma

Subjects:

Others > Medicine
Others > Pharmacy
Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

15 Jul 2022 10:04

Last Modified:

15 Jul 2022 10:04

URI:

http://raiithold.iith.ac.in/id/eprint/9733