Modulating catalytic activity of a modified flavin analogue via judicially positioned metal ion toward aerobic sulphoxidation

Mouli, M. S. S. Vinod and Mishra, Ashutosh Kumar (2022) Modulating catalytic activity of a modified flavin analogue via judicially positioned metal ion toward aerobic sulphoxidation. RSC Advances, 12 (7). pp. 3990-3995. ISSN 2046-2069

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Abstract

This manuscript describes the synthesis, spectroscopic and crystallographic characterization of a cadmium complex of 10-propoylisoalloxazine-7-carboxylic acid (Flc-Cd). Catalytic activity of Flc-Cd towards aerobic sulphoxidation reaction was investigated in the presence of l-ascorbic acid as the reducing agent. Notably the neutral un-metalated flavin analogue did not show any significant catalytic activity. The design strategy for Flc provides a close proximity of the metal centre to the flavin core without compromising the catalytic site thereby assisting the product formation when compared to unmetallated Flc. Minor enantioselectivity is also observed in cases where unsymmetrical sulphides were used; indicative of the possible involvement of chiral l-ascorbic acid in the intermediate formation. This journal is © The Royal Society of Chemistry.

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IITH Creators:

IITH Creators	ORCiD
Mishra, Ashutosh Kumar	https://orcid.org/0000-0001-8697-7741

Item Type:

Article

Uncontrolled Keywords:

Cadmium complex; Catalytic sites; Close proximity; Crystallographic characterization; Design strategies; L(+)-ascorbic acid; Metal centres; Metals ions; Spectroscopic characterization; Sulphoxidation

Subjects:

Chemistry

Divisions:

Department of Chemistry

Depositing User:

. LibTrainee 2021

Date Deposited:

20 Jul 2022 12:12

Last Modified:

20 Jul 2022 12:12

URI:

http://raiithold.iith.ac.in/id/eprint/9672