Flow driven vesicle unbinding under mechanosensitive adhesion

Rizvi, Mohd Suhail and Farutin, Alexander and Misbah, Chaouqi (2022) Flow driven vesicle unbinding under mechanosensitive adhesion. Soft Matter, 18 (6). pp. 1209-1218. ISSN 1744-683X

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Abstract

Ligand receptor based adhesion is the primary mode of interaction of cellular blood constituents with the endothelium. These adhered entities also experience shear flow imposed by the blood which may lead to their detachment due to the viscous lift forces. Here, we have studied the role of the ligand-receptor bond kinetics in the detachment of an adhered vesicle (a simplified cell model) under shear flow. Using boundary integral formulation we performed numerical simulation of a two dimensional vesicle under shear flow for different values of applied shear rates and time scale of bond kinetics. We observe that the vesicle demonstrates three steady state configurations-adhered, pinned and detached for fast enough ligand-receptor kinetics (akin to Lennard-Jones adhesion). However, for slow bond kinetics the pinned state is not observed. We present scaling laws for the critical shear rates corresponding to the transitions among these three states. These results can help with identifying the processes of cell adhesion/detachment in the blood stream, prevalent features during the immune response and cancer metastasis. This journal is © The Royal Society of Chemistry.

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IITH Creators:

IITH Creators	ORCiD
Rizvi, Mohd Suhail	https://orcid.org/0000-0002-4130-4671

Item Type:

Article

Additional Information:

We thank CNES (Centre National d’Etudes Spatiales), and the French-German University Programme ‘‘Living Fluids’’ (Grant CFDA-Q1-14) for a financial support. MSR also thanks IIT Hyderabad for the seed grant for some part of this work.

Uncontrolled Keywords:

Boundary integral formulations; Cell model; Cellulars; Lennard Jones; Lift force; Ligand-receptor; Shear-rate; Steady state; Time-scales; Two-dimensional

Subjects:

Biomedical Engineering
Physics

Divisions:

Department of Biomedical Engineering
Department of Physics

Depositing User:

. LibTrainee 2021

Date Deposited:

13 Jul 2022 12:23

Last Modified:

13 Jul 2022 12:23

URI:

http://raiithold.iith.ac.in/id/eprint/9649