A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base‐sensitive cargo

Chauhan, Meenakshi and Basu, Suparna Mercy and Giri, Jyotsnendu and et al, . (2022) A facile strategy for the preparation of polypropylene sulfide nanoparticles for hydrophobic and base‐sensitive cargo. Journal of Applied Polymer Science, 139 (10). p. 51767. ISSN 0021-8995

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Abstract

Polypropylene sulfide (PPS) as reactive oxygen species (ROS) responsive nanoparticles (NPs) have attained great interest for drug delivery applications in many diseases such as cancer, pulmonary, neurovascular, cardiovascular, and age-related diseases. Despite great potential of PPS NPs as a nanocarrier, it remains relatively less explored for small molecules (drug) delivery, as the current method of PPS NPs synthesis involving strong bases like sodium methoxide (NaOMe) and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) results in breakdown of base sensitive drugs or molecules. Herein, we are reporting a facile synthesis method for PPS NPs preparation with high drug loading capacity (five times higher than the reported synthesis method) of base-sensitive cargos (Paclitaxel/Dil dye) within the PPS matrix and protection from possible breakdown of drug during synthesis. The NPs prepared via our method possess oxidative-responsive release of drug, preservation of drug bioactivity, and excellent storage stability at room temperature or 4°C. PPS NPs system demonstrate biocompatibility and drug-loaded NPs provide efficient anticancer activity against breast cancer cells. Our method of PPS NPs synthesis is suitable to prepare a delivery system with higher loading capacity of drug and small molecules for different biomedical applications. © 2021 Wiley Periodicals LLC.

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IITH Creators:

IITH Creators	ORCiD
Giri, Jyotsnendu	UNSPECIFIED

Item Type:

Article

Additional Information:

Authors would like to thank the Department of Biotechnology (DBT), India for financial support (Project Nos.—BT/PR14629/NNT/28/823/2015 and BT/RLF/Re‐entry‐21‐2013) and the Department of Science & Technology (DST), India (Project No.—DST/IMRCD/EU/INNO‐INDIGO/NANOBREASTCO/2015). M.C., S.M.B., and S.K.Y. acknowledge MHRD, India for financial support.

Uncontrolled Keywords:

biocompatible; cancer; drug delivery; oxidation-sensitive; paclitaxel; polypropylene sulphide nanoparticles

Subjects:

Others > Biochemistry
Others > Biotechnology
Biomedical Engineering
Chemistry

Divisions:

Department of Biomedical Engineering
Department of Biotechnology
Department of Chemistry

Depositing User:

. LibTrainee 2021

Date Deposited:

22 Jul 2022 06:29

Last Modified:

22 Jul 2022 06:29