Cross-linker-free sodium alginate and gelatin hydrogels: a multiscale biomaterial design framework

Basu, Tithi and Bhutani, Utkarsh and Majumdar, Saptarshi (2022) Cross-linker-free sodium alginate and gelatin hydrogels: a multiscale biomaterial design framework. Journal of Materials Chemistry B, 10 (19). pp. 3614-3623. ISSN 2050-750X

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Abstract

Surface functionalization and cross-linking have been adopted extensively by researchers to customize hydrogel properties, especially in the last decade. The clinical translation of such biomaterials is in a poor state due to long-term toxicity, often beyond the periphery of the short-term animal studies. We endeavor to relook at the material development strategy with all FDA-approved biopolymers in their native states, like gelatin and sodium alginate, without using any functionalization and cross-linking. The fabrication of a cross-linker-free hydrogel has remained one of the main challenges in biomaterial design and requires multiscale structuring of the hydrogels. The physical properties of these hydrogels were enhanced by plasticizers (PEG and glycerol) and a monovalent salt (NaCl). An in-depth analysis suggested that PEG forms a plasticizing layer at the sodium alginate and gelatin interface and glycerol alters the overall polymer structure. The results were further complemented by different characterization methods (scattering techniques and infrared spectroscopy) and molecular dynamics simulations. The detailed microstructural analysis surfaced the enthralling integrated swelling mechanism in gelatin chains that led to high-performing hydrogels. © 2022 The Royal Society of Chemistry

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IITH Creators:

IITH Creators	ORCiD
Majumdar, Saptarshi	UNSPECIFIED

Item Type:

Article

Additional Information:

The authors would like to acknowledge Mr Kali Suresh and Dr Chandra Shekhar Sharma (Associate Professor, IIT Hyderabad) for their help during SAXS measurements and IIT Hyderabad for providing all the research facilities. The authors thank Dr Debaprasad Shee (Associate Professor, IIT Hyderabad) gratefully for his valuable technical inputs. The authors acknowledge financial approval from DST (Dept. of Science & Technology, Govt. of India) funding CRG/2021/001039. The authors would like to acknowledge BioRender.com. The schematics were prepared with the help of BioRender. Author 1 and author 2 contributed equally to this work.

Uncontrolled Keywords:

Alginate hydrogels; Animal studies; Clinical translation; Cross linking; Crosslinker; Design frameworks; Gelatin hydrogels; Material development; Property; Surface Functionalization

Subjects:

Others > Medicine
Chemical Engineering

Divisions:

Department of Chemical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

02 Jul 2022 07:16

Last Modified:

13 Jul 2022 10:40

URI:

http://raiithold.iith.ac.in/id/eprint/9464