Doxorubicin loaded polyvinylpyrrolidone-copper sulfide nanoparticles enabling mucoadhesiveness and chemo-photothermal synergism for effective killing of breast cancer cells

R, G. and S, R.P. and Thomas, A. and Rengan, A.K. (2021) Doxorubicin loaded polyvinylpyrrolidone-copper sulfide nanoparticles enabling mucoadhesiveness and chemo-photothermal synergism for effective killing of breast cancer cells. Materialia, 19 (101195). ISSN 25891529

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Abstract

The synergistic effect of chemo-photothermal therapy by near-infrared light-responsive nanoparticles is being widely researched. The combination of chemo-photothermal effects reduces the regrowth of tumor residuals by enhancing therapeutic coverage when compared with a single treatment modality. In the current study, doxorubicin hydrochloride-loaded polyvinylpyrrolidone-copper sulfide nanoparticles (DP-CuS NPs) were synthesized by a facile one-pot method. DP-CuS NPs showed good muco-adherence and also acted as an efficient chemo-photothermal agent. The polyvinylpyrrolidone (PVP) coating prevented the aggregation of CuS NPs and helped in stabilizing the size (hydrodynamic diameter ̴35nm) of the synthesized nanoparticle. PVP also served as a cargo, enabling the loading of a chemotherapeutic drug (doxorubicin) with an efficiency of ̴75 %. The localized release of doxorubicin was achieved by photothermal/pH trigger upon DP-CuS NPs, enhancing therapeutic efficiency. DP-CuS NPs, when treated with breast cancer cell line (MCF 7), exhibited efficient cancer cell cytotoxicity (cell viability: ̴11 %) and photothermal triggered mucolytic properties. These nanoparticles were also effective in preventing the growth of residual cancer cells through their mucolytic property and chemo-photothermal dual therapeutic effect. © 2021

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IITH Creators:
IITH CreatorsORCiD
Rengan, Aravind Kumarhttps://orcid.org/0000-0003-3994-6760
Item Type: Article
Uncontrolled Keywords: Chemo-photothermal therapy, Copper sulfide nanoparticles, Doxorubicin, Mucoadhesive property, Polyvinylpyrrolidone, Triggered drug release
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: Mrs Haseena VKKM
Date Deposited: 14 Mar 2022 10:00
Last Modified: 14 Mar 2022 10:00
URI: http://raiithold.iith.ac.in/id/eprint/9184
Publisher URL: https://www.sciencedirect.com/science/article/pii/...
OA policy: https://v2.sherpa.ac.uk/id/publication/35834
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