Study of effects of triclosan and glyphosate on living organisms.

Umale, Ashwini Anil and Bhargava, Anamika (2021) Study of effects of triclosan and glyphosate on living organisms. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Several scientific studies of the past have suggested a link between increased exposure to pollutants and a rise in the number of neurodegenerative disorders of unknown origin. Notably, triclosan which is marketed as an antimicrobial agent is used in high concentrations in various consumer products. Recent studies have also highlighted triclosan as an emerging toxic pollutant due to its growing global use. However, a definitive link is missing to associate the rising use of triclosan and the growing number of neurodegenerative disorders. In this article, we present systematic scientific evidences which are otherwise scattered to suggest that triclosan has can induce potent neurotoxic effects, especially in vertebrate organisms including humans. Mechanistically, triclosan affected important developmental and differentiation genes, structural genes, genes for signaling receptors and genes for neurotransmitter controlling enzymes. Triclosan directly induced oxidative stress impacting cellular homeostasis and inducing apoptosis. The scientific evidence collated in this article unequivocally indicates that triclosan may be one stressor causing neurodegeneration.

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