Understanding the role of T-type VGCC and ER-β in Triple-Negative Breast Cancer

Sahu, Chittaranjan and Bhargava, Anamika (2020) Understanding the role of T-type VGCC and ER-β in Triple-Negative Breast Cancer. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Triple-Negative Breast Cancer (TNBC) doesn’t express Estrogen Receptor-α (ER-α), Progesterone Receptor (PR), and Human Epidermal Growth Receptor (HER 2). Out of the total breast cancers reported, 15-20% are of TNBC type. Out of the overall mortality caused in breast cancer, 50% of the death is caused due to TNBC alone. Due to the absence of these growth receptors, the TNBC cannot be treated using traditional therapies targeting these growth receptors. Therefore it is important to identify new receptors and channels that can be targeted to treat the TNBC.

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