Basuli, S and Chinnabattigalla, S and Gupta, K and Gedu, S
(2021)
A concise route towards isoflavans.
Journal of Heterocyclic Chemistry, 58 (1).
pp. 182-194.
ISSN 1943-5193
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Abstract
Isoflavans have gained considerable interest owing to their potential health benefits. Herein, we have presented a straightforward strategy for isoflavans synthesis. The strategy features an intermolecular [Cu]-catalyzed arylation of malonates and an intramolecular [Pd]-catalyzed Buchwald coupling of hydroxy tethered bromoarenes as the key transformations. This protocol enabled the synthesis of a variety of isoflavan analogs.
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