Self-Assembled Fluorosome–Polydopamine Complex for Efficient Tumor Targeting and Commingled Photodynamic/Photothermal Therapy of Triple-Negative Breast Cancer

P.S, Rajalakshmi and Alvi, Syed Baseeruddin and Begum, Nazia and Veeresh, Bantal and Rengan, Aravind Kumar (2021) Self-Assembled Fluorosome–Polydopamine Complex for Efficient Tumor Targeting and Commingled Photodynamic/Photothermal Therapy of Triple-Negative Breast Cancer. Biomacromolecules, 22 (9). pp. 3926-3940. ISSN 1525-7797

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Abstract

Photodynamic/photothermal therapy (PDT/PTT) that deploys a near-infrared responsive nanosystem is emerging to be a promising modality in cancer treatment. It is highly desirable to have a multifunctional nanosystem that can be used for efficient tumor targeting and inhibiting metastasis/recurrence of cancer. In the current study, self-assembled chlorophyll-rich fluorosomes derived from Spinacia oleracea were developed. These fluorosomes were co-assembled on a polydopamine core, forming camouflaged nanoparticles (SPoD NPs). The SPoD NPs exhibited a commingled PDT/PTT (i.e., interdependent PTT and PDT) that inhibited both normoxic and hypoxic cancer cell growth. These nanoparticles showed stealth properties with enhanced physiological stability and passive tumor targeting. SPoD NPs also exhibited tumor suppression by synergistic PTT and PDT. It also prevented lung metastasis and splenomegaly in tumor-bearing Balb/c mice. Interestingly, treatment with SPoD NPs also caused the suppression of secondary tumors by eliciting an anti-tumor immune response. In conclusion, a co-assembled multifunctional nanosystem derived from S. oleracea showed enhanced stability and tumor-targeting efficacy, resulting in a commingled PDT/PTT effect

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IITH Creators:
IITH CreatorsORCiD
P.S, RajalakshmiUNSPECIFIED
Alvi, Syed BaseeruddinUNSPECIFIED
Rengan, Aravind KumarUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: Anti-tumor immune; Cancer cell growth; Enhanced stability; Lung metastasis; Spinacia oleracea; Stealth property; Triple-negative breast cancers; Tumor suppression
Subjects: Biomedical Engineering
Divisions: Department of Biomedical Engineering
Depositing User: . LibTrainee 2021
Date Deposited: 23 Sep 2021 10:28
Last Modified: 23 Sep 2021 10:28
URI: http://raiithold.iith.ac.in/id/eprint/8848
Publisher URL: http://doi.org/10.1021/acs.biomac.1c00744
OA policy: https://v2.sherpa.ac.uk/id/publication/7768
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