Biodegradable/disintegrable nanohybrids for photothermal theranostics

Singh, Surya Prakash and Appidi, Tejaswini and Rengan, Aravind Kumar (2021) Biodegradable/disintegrable nanohybrids for photothermal theranostics. Proceedings of the Indian National Science Academy, 87 (1). pp. 94-106. ISSN 0370-0046

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Abstract

Nanohybrids using biocompatible and biodegradable materials are explored for their photothermal mediated theranostic applications. These hybrids are so chosen that they are biocompatible and biodegradable. Gold-based different nanosystems have NIR absorption which is highly favored for PTT, but they are limited by their toxicity, stability, and clearance. To overcome these challenges, we have demonstrated thermosensitive liposome-gold hybrid nanosystem for photothermal therapy and its clearance in vivo for the first time. We have also explored the possibility of using the same hybrid as drug (curcumin) carrier for triggered delivery and were successful in using curcumin as an adjuvant to PTT. Thermoresponsive polymers coated with gold for photothermal therapy and X-ray imaging of deep seated tumors has been evaluated. Fluorescent Poly (ethylene glycol) encapsulated metal nanoparticles were also synthesized and their application for cancer theranostics has been explored. Biodegradable and biocompatible polymer (PLGA) and liposomes loaded with anticancer plant fraction and a NIR dye showed synergistic photo-chemo therapy against cancer in-vitro & in-vivo. The intracellular changes with PTT and the mechanistic action of anti-cancer agent were explored in detail.

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IITH Creators:

IITH Creators	ORCiD
Singh, Surya Prakash	UNSPECIFIED
Appidi, Tejaswini	UNSPECIFIED
Rengan, Aravind Kumar	UNSPECIFIED

Item Type:

Article

Uncontrolled Keywords:

Autophagy; Biodegradable nanohybrids; Combinative approach; Enhanced permeability and retention effect; Photothermal therapy; Reactive oxygen species;Biocompatibility; Biodegradable polymers; Diseases; Drug delivery; Gold coatings; Infrared devices; Liposomes; Metal nanoparticles; Nanostructured materials; Nanosystems; Polyethylene glycols; Synthesis (chemical)

Subjects:

Electrical Engineering
Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

23 Sep 2021 10:20

Last Modified:

23 Sep 2021 10:20

URI:

http://raiithold.iith.ac.in/id/eprint/8847