Brønsted acid-induced synthesis of methyl benzofurans via Grob type fragmentation of norbornyl derivatives

Sravanthi, Kadavergu and Khan, Faiz Ahmed (2020) Brønsted acid-induced synthesis of methyl benzofurans via Grob type fragmentation of norbornyl derivatives. Tetrahedron Letters, 61 (38). p. 152351. ISSN 00404039

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Abstract

An efficient Brønsted acid-induced one-pot syntheses of 2-methylbenzofurans from norbornyl derivatives have been reported. The construction of new C–O bond proceeds via Grob-type fragmentation followed by cyclization and aromatization respectively. This synthetic strategy facilitates the efficient synthesis of 2-methylbenzofurans under acidic conditions. Significantly, this methodology is successfully applied to the synthesis of 6,7-bisaryl benzofurans.

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IITH Creators:

IITH Creators	ORCiD
Sravanthi, Kadavergu	UNSPECIFIED
Khan, Faiz Ahmed	UNSPECIFIED

Item Type:

Article

Uncontrolled Keywords:

aromatization; Article; chemical structure; cyclization; dehalogenation; fragmentation reaction; Grob fragmentation; halogenation; one pot synthesis; proton nuclear magnetic resonance; reaction optimization; substitution reaction; Suzuki reaction; tautomer

Subjects:

Chemistry

Divisions:

Department of Chemistry

Depositing User:

. LibTrainee 2021

Date Deposited:

19 Jul 2021 06:13

Last Modified:

19 Jul 2021 06:13

URI:

http://raiithold.iith.ac.in/id/eprint/8422