3D hepatic mimics – the need for a multicentric approach

Sasikumar, Shyama and Chameettachal, Shibu and Kingshott, Peter and Cromer, Brett and Pati, Falguni (2020) 3D hepatic mimics – the need for a multicentric approach. Biomedical Materials, 15 (5). 052002. ISSN 1748-605X

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Abstract

The liver is a center of metabolic activity, including the metabolism of drugs, and consequently is prone to drug-induced liver injury. Failure to detect hepatotoxicity of drugs during their development will lead to the withdrawal of the drugs during clinical trials. To avoid such clinical and economic consequences, in vitro liver models that can precisely predict the toxicity of a drug during the pre-clinical phase is necessary. This review describes the different technologies that are used to develop in vitro liver models and the different approaches aimed at mimicking different functional aspects of the liver at the fundamental level. This involves mimicking of the functional and structural units like the sinusoid, the bile canalicular system, and the acinus.

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IITH Creators:

IITH Creators	ORCiD
Sasikumar, Shyama	UNSPECIFIED
Chameettachal, Shibu	UNSPECIFIED
Pati, Falguni	http://orcid.org/0000-0002-3588-1800

Item Type:

Article

Uncontrolled Keywords:

bile canaliculus; biological model; human; in vitro study; liver; liver sinusoid; liver tissue; nonhuman; Review; three dimensional bioprinting; tissue engineering; tumor spheroid;Bile canalicular; Clinical trial; Economic consequences; Functional aspects; Hepatotoxicity; Liver injuries; Metabolic activity; Structural unit

Subjects:

Biomedical Engineering

Divisions:

Department of Mechanical & Aerospace Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

10 Jul 2021 06:03

Last Modified:

10 Jul 2021 06:03

URI:

http://raiithold.iith.ac.in/id/eprint/8211