Application of kohonen-self organizing map to cluster drug induced Ca2+ response in hippocampal neurons at different drug dose

Saxena, Abha and Dhyani, Vaibhav and Jana, Soumya and Giri, Lopamudra (2020) Application of kohonen-self organizing map to cluster drug induced Ca2+ response in hippocampal neurons at different drug dose. In: Indian Institute of Technology Hyderabad, 21 February 2020 - 23 February 2020.

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Abstract

Recent advancement in neuronal imaging leads to accurate measurement of cellular activity after treatment with drugs. However, neuronal activity obtained by dynamic imaging reveals complex pattern with time, the prediction of activity level corresponding to drug level remains challenging. In this context, we apply self organizing map (SOM) to estimate the drug dose according to neuronal activity level in four different time windows. Here we cluster the neuronal activity pattern and classify the activity pattern with drug dose. We also implement supervised SOM to predict the drug dose corresponding to activity pattern. The advantage of using SOM is that it is a great visualization and prediction tool to analyze high-dimensional data onto a low-dimensional (1D or 2D) SOM grid. Such computaional tool can be used to classify unknown neuronal responses according to the extent of drug level present in the system.

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IITH Creators:

IITH Creators	ORCiD
Saxena, Abha	UNSPECIFIED
Dhyani, Vaibhav	UNSPECIFIED
Jana, Soumya	UNSPECIFIED
Giri, Lopamudra	http://orcid.org/0000-0002-2352-7919

Item Type:

Conference or Workshop Item (Paper)

Uncontrolled Keywords:

Accurate measurement; Cellular activities; Different time windows; High dimensional data; Hippocampal neurons; Kohonen self-organizing maps; Neuronal activities; Neuronal response

Subjects:

Chemical Engineering

Divisions:

Department of Chemical Engineering

Depositing User:

. LibTrainee 2021

Date Deposited:

09 Jul 2021 07:10

Last Modified:

09 Jul 2021 07:10

URI:

http://raiithold.iith.ac.in/id/eprint/8191