Duraiand, Lignesh and Badhulika, Sushmee
(2021)
Ultra-Selective and Wide Range Detection of D-Mannitol in Human Blood Samples via Differential Pulse Voltammetry Technique Using MgAl2O4 Perovskite Modified Electrode.
IEEE Sensors Journal, 21 (5).
pp. 5736-5742.
ISSN 1530-437X
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Abstract
Herein, we present the first report on label-free electrochemical sensing of D-Mannitol using MgAl2O4 Nanopowder (MAO) modified glassy carbon electrode (GCE) sensor for pico-molar detection of D-Mannitol in biological samples. The differential pulse voltammetry (DPV) technique is employed for the sensing of D-Mannitol over a wide linear range of detection ranging from 1 pM to 1.5 nM with a sensitivity of 6.47 nA/pM cm-2 and an ultra-low limit of detection (LOD, 3σ) of 0.371 pM. The sensor shows an excellent selectivity towards D-Mannitol in the presence of interfering analytes such as glucose, sucrose, human serum albumin (HSA) and bovine serum albumin (BSA). Additionally, the sensor exhibits successful reproducibility with n = 5 devices and excellent stability. This enhanced performance of the MAO/GCE is attributed to the excellent electrocatalytic property of MAO thru Al2+/Al2+ redox couple facilitating the redox reaction of D-Mannitol and the presence of oxy functional groups which improves the adsorption process of D-Mannitol oxidase (mannose) onto the surface of MAO/GCE. The as-fabricated sensor could successfully determine D-Mannitol in the biological samples with excellent recovery percentages from 98.2% to 110.42% thus proving to be an excellent platform for developing low cost, high-performance bioanalytical sensing systems.
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