Modeling Fluoroquinolone Resistance in Polluted Aquatic Environment of a River

Gothwal, R and Thatikonda, Shashidhar (2021) Modeling Fluoroquinolone Resistance in Polluted Aquatic Environment of a River. Journal of Hazardous, Toxic, and Radioactive Waste, 25 (2). ISSN 2153-5493

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Abstract

Excess use of antibiotics has led to antibiotic pollution in the environment, and now polluted sites have become hotspots for evolution and spread of antibiotic resistance in environmental bacteria. Subinhibitory concentration of antibiotics combined with other pollutant exerts selective pressure on environmental microbes, driving evolution and spreading antibiotic resistance. A mathematical model has been developed to have a better understanding of the subject of development of antibiotic resistance and its management in the aquatic environment. The model includes state variables such as fluoroquinolone, organic matter, heavy metals, resistant bacteria, and susceptible bacteria. The model was applied to the Musi River, which is heavily polluted with antibiotics. Simulations were carried out with hydraulic conditions and initial boundary conditions for state variables using actual site-specific data. Spatial pattern predicted by simulated results of the model is able to match with the observed spatial pattern of proliferation of resistance in the river. The developed model is also simulated for different pollution loading scenarios to predict and compare the future conditions for the river management. The simulated results showed that factors such as substrate concentration, antibiotic concentration, horizontal rate of transfer of plasmid, total population density of bacteria, and rate of losing plasmid dictate the dynamics of resistance in the river.

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IITH Creators:

IITH Creators	ORCiD
Thatikonda, Shashidhar	https://orcid.org/0000-0003-2973-2224

Item Type:

Article

Uncontrolled Keywords:

Antibiotic pollution,Antibiotic resistance,Aquatic environment,Fate and transport model,Fluoroquinolone Antibiotics,Bacteria,DNA,Heavy metals,Population statistics,Rivers Antibiotic concentration,Antibiotic resistance,Aquatic environments,Environmental microbes,Hydraulic conditions,Pollution loadings,Population densities,Substrate concentrations, River pollution

Subjects:

Civil Engineering > Water resources engineering

Divisions:

Department of Civil Engineering

Depositing User:

Team Library

Date Deposited:

29 Dec 2020 01:03

Last Modified:

29 Dec 2020 01:05

URI:

http://raiithold.iith.ac.in/id/eprint/7626