Acid mediated synthesis of thiazolines, thiazoles and enamide derivatives from methyl enol ethers: Application towards synthesis of wilsoniamine B

Jena, Tapan Kumar and Khan, Faiz Ahmed (2020) Acid mediated synthesis of thiazolines, thiazoles and enamide derivatives from methyl enol ethers: Application towards synthesis of wilsoniamine B. Tetrahedron Letters. ISSN 0040-4039 (In Press)

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Abstract

An efficient metal-free synthesis of thiazolines, dihydrothiazole and enureas or thioureas from methyl enol ether with urea or thiourea derivatives in the presence of TFA (trifluoroacetic acid) are reported here. This synthetic protocol involves the formation of two bonds, C–N as well as C–S, in one step for the synthesis of thiazoline derivatives, dihydrothiazoles and a direct C–N bond for the synthesis of enamides with good to excellent yields. Further, this method was employed for the synthesis of wilsoniamine B alkaloid.

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IITH Creators:	IITH Creators ORCiD Khan, Faiz Ahmed UNSPECIFIED
Item Type:	Article
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	03 Feb 2020 06:13
Last Modified:	03 Feb 2020 06:13
URI:	http://raiithold.iith.ac.in/id/eprint/7391
Publisher URL:	https://doi.org/10.1016/j.tetlet.2020.151675
Related URLs:	Google Scholar

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