Template Assisted Micro-Patterned Electrospun Nanofibrous Mat As a Potential Carrier for Controlled Drug Release

Kakunuri, Manohar and Khandelwal, Mudrika and Sharma, Chandra Shekhar and et al, . (2017) Template Assisted Micro-Patterned Electrospun Nanofibrous Mat As a Potential Carrier for Controlled Drug Release. In: AICHE Annual Meeting, 16-21 October 2011, Minneaolis, USA..

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Abstract

Controlled drug release by manipulating the surface wettability and degradability of the drug carrier is essential for medical treatments.1 Usually, the wettability of a surface can be altered by surface coatings and by changing the surface roughness. In this work we have fabricated micro-patterned cellulose acetate electrospun nanofibrous mats using template assisted electrospinning (Figure 1A). This approach produces mats with tunable wettability. Nylon meshes (Figure 1B) with different grid spacing (50 µm, 100 µm and 200 µm) were used as a template to fabricate micro-patterned nanofabric over a large area (10 × 10 cm2) in a single step. This non-conductive nylon mesh in strong electrostatic field polarizes and generates a negative static charge on the nylon mesh by static induction and polarization.2 Further, the nylon grid attracts fibers onto grid lines and forms micropatterned fiber mats as shown in Figure 1 (A). Initially, fibers are preferably deposited on nylon grid lines. After 10 min of deposition, the fibers repel incoming material resulting in a random deposition to yield micro-patterned nanofabric surfaces as shown in Figure 1C. Water contact angle measurements were performed on these micro-patterned nanofibrous mats fabricated with different spacing to study the effect of micropatterning on wettability. As shown in Figure 1C, these micro-patterned surfaces form non-communicating air gaps and air trapped in this gaps minimizes the solid-water interface and opposes wetting by capillary action. This non-wetting pressure plays a key role in the wettability of non-commuting air trapped systems.3 The Water Contact Angle (WCA) changes from 30° for the non-patterned surface to 138° for a micro-patterned surface with a 50 µm spacing. This change in WCA can be attributed to capillary pressure increases with decreasing spacing. WCA measurements are summarized in Figure 1D. Further, the effect of surface wettability on drug release kinetics was investigated by loading Diclofenac sodium into cellulose acetate precursor solutions prior to electrospinning. Transdermal drug releases study shown a significant change in drug release kinetics with a change in surface wettability. Micro-patterned surfaces with a WCA of 138° showed zero order release kinetics up to 12 hours, whereas non-patterned hydrophilic (30°) samples only showed controlled drug release for 1 hr.

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