Intracranial pressure–based validation and analysis of traumatic brain injury using a new three-dimensional finite element human head model

Khanuja, Tanu and Unni, Harikrishnan Narayanan (2020) Intracranial pressure–based validation and analysis of traumatic brain injury using a new three-dimensional finite element human head model. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 234 (1). pp. 3-15. ISSN 0954-4119

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Abstract

Traumatic brain injuries are life-threatening injuries that can lead to long-term incapacitation and death. Over the years, numerous finite element human head models have been developed to understand the injury mechanisms of traumatic brain injuries. Many of these models are erroneous and used ellipsoidal or spherical geometries to represent brain. This work is focused on the development of high-quality, comprehensive three-dimensional finite element human head model with accurate representation of cerebral sulci and gyri structures in order to study traumatic brain injury mechanisms. Present geometry, predicated on magnetic resonance imaging data consist of three rudimentary components, that is, skull, cerebrospinal fluid with the ventricular system, and the soft tissues comprising the cerebrum, cerebellum, and brain stem. The brain is modeled as a hyperviscoelastic material. Meshed model with 10 nodes modified tetrahedral type element (C3D10M) is validated against two cadaver-based impact experiments by comparing the intracranial pressures at different locations of the head. Our results indicate a better agreement with cadaver results, specifically for the case of frontal and parietal intracranial pressure values. Existing literature focuses mostly on intracranial pressure validation, while the effects of von Mises stress on brain injury are not analyzed in detail. In this work, a detailed interpretation of neurological damage resulting from impact injury is performed by analyzing von Mises stress and intracranial pressure distribution across numerous segments of the brain. A reasonably good correlation with experimental data signifies the robustness of the model for predicting injury mechanisms based on clinical predictions of injury tolerance criteria.

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IITH Creators:

IITH Creators	ORCiD
Unni, Harikrishnan Narayanan	https://orcid.org/0000-0001-8678-7665

Item Type:

Article

Additional Information:

Khanuja Tanu 1 https://orcid.org/0000-0001-8678-7665 Unni Harikrishnan Narayanan 2 1 Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, India 2 Biomicrofluidics and Biomechanics Lab, Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, India Harikrishnan Narayanan Unni, Biomicrofluidics and Biomechanics Lab, Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy District, Hyderabad 502285, Telangana, India. Email: harikrishnan@iith.ac.in 10 2019 0954411919881526 27 5 2019 13 9 2019 © IMechE 2019 2019 Institution of Mechanical Engineers Traumatic brain injuries are life-threatening injuries that can lead to long-term incapacitation and death. Over the years, numerous finite element human head models have been developed to understand the injury mechanisms of traumatic brain injuries. Many of these models are erroneous and used ellipsoidal or spher ...

Uncontrolled Keywords:

finite element model, hyperviscoelastic, intracranial pressure, magnetic resonance imaging, Traumatic brain injury, von Mises stress, Indexed in Scopus and WoS

Subjects:

Biomedical Engineering

Divisions:

Department of Biomedical Engineering

Depositing User:

Team Library

Date Deposited:

18 Nov 2019 05:41

Last Modified:

24 Nov 2022 11:18

URI:

http://raiithold.iith.ac.in/id/eprint/7024