Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines

Das, Suman and Karmakar, Himadri and Bhattacharjee, Jayeeta and Panda, Tarun K (2019) Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines. Dalton Transactions, 48 (31). pp. 11978-11984. ISSN 1477-9226

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Abstract

We report an efficient protocol for the catalytic chemo-selective reduction of tert-amides with pinacolborane (HBpin) to afford the corresponding amines in high yields using aluminium complexes [κ2-{Ph2P(X)NC9H6N}Al(Me)2] [X = S (2a), Se (2b)] as pre-catalysts at room temperature. The aluminium complexes were prepared from the reaction of [Ph2P(X)NC9H6N] [X = S (1a), Se (1b)] and trimethylaluminium in toluene. The solid-state structure of complex 2b is established. Tertiary amides with a wide array of electron-withdrawing and electron-donating functional groups were easily converted to the desired products through the selective cleavage of the amides' CO bond by aluminium hydride as an active species. A kinetic study of the catalytic reaction is also reported.

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