Convenient Synthesis of Substituted Quinolines by Iodine Catalysis intramolecular annulations of � - enamino-esters

Rawat, Vishal Kumar and D S, Sharada (2019) Convenient Synthesis of Substituted Quinolines by Iodine Catalysis intramolecular annulations of � - enamino-esters. Masters thesis, Indian institute of technology Hyderabad.

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Abstract

The synthesis of highly substituted Quinoline compounds is of crucial importance in many areas of science, including biology, medicine, biotechnology, chemistry and are one of the most abundant and principle feedstock and thus represent excellent prospective building blocks for chemical synthesis. Therefore, there is a fundamental interest in developing new approaches for production of highly substituted Quinoline scaffolds. Here we demonstrate the first time synthesis of substituted Quinolines scaffolds by intramolecular annulations of ambient �-enaminoesters through Iodine catalysis is disclosed via Aza Micheal addition reaction. This procedure provides a metal free substitute for the synthesis of artificially relevant Quinolines from in situ achieved �-enaminoesters beneath moderate conditions. Such structural scaffolds are important precursors for the further transformations into biologically active compounds and synthetic useful intermediates.

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