D E, Sindhuja and Rath, Subha Narayan
(2018)
Co-cultured Mesenchymal Stem Cell Differentiation on 3D
Printed Scaffolds for Bone Tissue Engineering.
PhD thesis, Indian institute of technology Hyderabad.
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Abstract
Mesenchymal stem cells (MSCs) have a great potential in the field of tissue engineering and
regenerative medicine due to their ability to self-renew and differentiate into various
lineages. They can be differentiated by chemical factors, mechanical stimulus, and electrical
potential among others. However, one of the strategies to enhance osteogenic differentiation
of MSCs is to co-culture them with endothelial cells (ECs) exploiting their cell-cell
interactions. In addition to differentiating into osteogenic, adipogenic and chondrogenic
lineages, MSCs can differentiate into endothelial phenotype
in vivo behavior can be reflected more accurately by a three-dimensional (3D) scaffold
environment than a two-dimensional (2D) planar surface. Hence, 3D bioprinting can be
used to provide a new opportunity for stem cell distribution, positioning, and differentiation
at the microscale to make the differentiated architecture of any tissue while maintaining
precision and control over the cellular microenvironment.
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