Total synthesis of enisorine D and its analogues

Shashi, and Khan, Faiz Ahmed (2019) Total synthesis of enisorine D and its analogues. Masters thesis, Indian institute of technology Hyderabad.

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Abstract

The first total synthesis of enisorine D, an inhibitor of T3SS dependent Yope secretion of Y. pseudotuberculosis isolated from a marine sponge Iotrochota cf. Iota is described in 63.7% overall yield. The target molecule was achieved in seven linear steps from tyramine via simple and effective transformations such as bromination, acylation, alkylation, azidation, reduction and routine acid-amine coupling. A total of sixteen analogues were prepared by coupling with eight different cinnamic acids, two bromopyrrole carboxylic acids and phenyl carboxylic acids.

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IITH Creators:	IITH Creators ORCiD Khan, Faiz Ahmed UNSPECIFIED
Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Total synthesis,Enisorine-D, Alkylation
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	13 May 2019 07:16
Last Modified:	13 May 2019 07:16
URI:	http://raiithold.iith.ac.in/id/eprint/5132
Publisher URL:
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