Domino [Pd]-Catalysis: Heck followed by decarboxylative Sonagashira couplings under microwave irradiation in aqueous medium

Karu, Ramesh and G, Satyanarayana (2019) Domino [Pd]-Catalysis: Heck followed by decarboxylative Sonagashira couplings under microwave irradiation in aqueous medium. Journal of Organometallic Chemistry. ISSN 0022-328X (In Press)

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Abstract

A copper free [Pd]-catalyzed domino intramolecular Heck and intermolecular decarboxylative Sonogashira couplings, for the synthesis of alkyne bearing heterocyclic compounds with a quaternary carbon atom, is described. Notably, this dual bond forming strategy is successful in water solvent, under microwave irradiation. This one-pot operation enabled the formation of a variety of dihydrobenzofurans, indolines and oxindoles, in very good to near quantitative yields. Notably, unlike earlier reports, the present strategy is successful in delivering the products with short alkyl substituents on acetylene carbon, which is first of its kind.

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IITH Creators:	IITH Creators ORCiD G, Satyanarayana UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	Pd-catalysis, Decarboxylation, Aqueous medium, Domino, Microwaves
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	28 Mar 2019 11:47
Last Modified:	28 Mar 2019 11:47
URI:	http://raiithold.iith.ac.in/id/eprint/4917
Publisher URL:	http://doi.org/10.1016/j.jorganchem.2019.03.015
OA policy:	http://sherpa.mimas.ac.uk/romeo/issn/0022-328X/
Related URLs:	Google Scholar

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