The Astrocyte–Neuron Interface: An Overview on Molecular and Cellular Dynamics Controlling Formation and Maintenance of the Tripartite Synapse

Hasan, Uzma and Singh, Sandeep K (2019) The Astrocyte–Neuron Interface: An Overview on Molecular and Cellular Dynamics Controlling Formation and Maintenance of the Tripartite Synapse. Methods in Molecular Biology, 1938. pp. 3-18. ISSN 1064-3745

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Abstract

Astrocytes are known to provide trophic support to neurons and were originally thought to be passive space-filling cells in the brain. However, recent advances in astrocyte development and functions have highlighted their active roles in controlling brain functions by modulating synaptic transmission. A bidirectional cross talk between astrocytic processes and neuronal synapses define the concept of tripartite synapse. Any change in astrocytic structure/function influences neuronal activity which could lead to neurodevelopmental and neurodegenerative disorders. In this chapter, we briefly overview the methodologies used in deciphering the mechanisms of dynamic interplay between astrocytes and neurons.

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IITH Creators:	IITH Creators ORCiD Singh, Sandeep K UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	Astrocyte, Brain organoids, hiPSC, Neural circuit, RGC, Tripartite synapse
Subjects:	Others > Biotechnology
Divisions:	Department of Biotechnology
Depositing User:	Team Library
Date Deposited:	30 Jan 2019 04:49
Last Modified:	30 Jan 2019 04:49
URI:	http://raiithold.iith.ac.in/id/eprint/4776
Publisher URL:	http://doi.org/10.1007/978-1-4939-9068-9_1
OA policy:	http://www.sherpa.ac.uk/romeo/issn/1064-3745/
Related URLs:	Google Scholar

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