An Approach to One-Pot Regioselective Synthesis of Indenones through Palladium-Catalyzed Annulation in Water

Karu, Ramesh and G, Satyanarayana (2018) An Approach to One-Pot Regioselective Synthesis of Indenones through Palladium-Catalyzed Annulation in Water. European Journal of Organic Chemistry, 2018 (30). pp. 4135-4146. ISSN 1434-193X

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Abstract

A one-pot synthesis of indenones is presented. The process involves palladium-catalyzed annulation of ortho-halobenzaldehydes with internal alkynes. Notably, it proceeded successfully in water as the sole, and green, solvent. Significantly, unlike in earlier reports, this protocol showed excellent regioselectivity with unsymmetrical alkylarylacetylenes. Further, the strategy was extended to a one-pot synthesis of a neolignan natural product.

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IITH Creators:	IITH Creators ORCiD G, Satyanarayana UNSPECIFIED
Item Type:	Article
Uncontrolled Keywords:	Pd catalysis, Domino reactions, Indenones, Annulation, Neolignans, Water chemistry, Green chemistry
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	24 Jan 2019 09:05
Last Modified:	24 Jan 2019 09:05
URI:	http://raiithold.iith.ac.in/id/eprint/4750
Publisher URL:	http://doi.org/10.1002/ejoc.201800591
Related URLs:	Google Scholar

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