Mathematical modelling of platelet rich plasma clotting. Pointwise unified model

Andreeva, Anna A and Mohan, Anand and Lobanov, Alexey I and Nikolaev, Andrey V and et al, . (2018) Mathematical modelling of platelet rich plasma clotting. Pointwise unified model. Russian Journal of Numerical Analysis and Mathematical Modelling, 33 (5). pp. 265-276. ISSN 0927-6467

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Abstract

The mechanistic modelling of blood clotting and fibrin-polymer mesh formation is of significant value for medical and biophysics applications. This paper presents a combination of two pointwise kinetic models represented by system of ODEs. One of them represents the reaction dynamics of clotting factors including the role of the platelet membranes. The second one describes the fibrin-polymer formation as a multistage polymerization process with a sol-gel transition at the final stage. Complex-value second order Rosenbrock method (CROS) is employed for the computational experiments. A sensitivity analysis method built into the computational scheme helps clarify non-evident dependencies in the exhaustive system of ODEs. The unified model was primarily verified using conditions of factor VII deficiency. The model, however requires a significant effort to be tested against experimental data available.

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