Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles

Murugan, Arumugavel and Gorantla, Koteswar Rao and Mallik, Bhabani Shankar and D S, Sharada (2018) Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles. Organic and Biomolecular Chemistry, 16 (28). pp. 5113-5118. ISSN 1477-0520

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Abstract

An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2 H -indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

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IITH Creators:	IITH Creators ORCiD Mallik, Bhabani Shankar http://orcid.org/0000-0001-9657-1497 D S, Sharada UNSPECIFIED
Item Type:	Article
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	30 Jul 2018 04:09
Last Modified:	30 Jul 2018 04:09
URI:	http://raiithold.iith.ac.in/id/eprint/4324
Publisher URL:	http://doi.org/10.1039/C8OB00931G
OA policy:	http://www.sherpa.ac.uk/romeo/issn/1477-0520/
Related URLs:	Google Scholar

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