Patient-specific Bone Defect Reconstruction using Bioactive Filament through 3D Printing

Soni, Raghav and Rath, Subha Narayan (2018) Patient-specific Bone Defect Reconstruction using Bioactive Filament through 3D Printing. Masters thesis, Indian Institute of Technology Hyderabad.

Text
Thesis_Mtech_BM_4110.pdf - Submitted Version
Restricted to Repository staff only until July 2020.
Download (1MB) | Request a copy

Abstract

There is a huge demand of new biomaterials for the repair or regeneration of large segmental bone defects. The current tissue engineering approach is mainly focused on synthetic materials or bioactive ceramics for osteoinduction and angiogenesis but struggling to achieve required high mechanical properties. Herein we describe the application of a composite prepared from PCL (poly-caprolactone) a biocompatible and biodegradable polymer which is known for its mechanical property along with borate bioactive glass (BBG,1393-B3) in a filament form, for 3D printing with FDM (fuse deposition modeling) based printer. We prepared and characterized the borate bioactive glass, which demonstrated in-vitro mineralization. For the preparation of printable composite filament, firstly we prepared PCL & BBG slurry by mixing 0%, 25%, 50% & 75% (W/W%) of BBG in PCL and chloroform. Using doctor blead casting, we prepared thin film (1mm thick) to perform swelling, degradation, pH test in PBS (phosphate buffer saline) and in-vitro mineralization in SBF (stimulated body fluid). The pellets prepared from this slurry has been served as an input material for filament preparation. This 3D printable PCL/BBG composite has the potential to serve as a biomaterial for patient specific bone defect reconstruction with high precision and accuracy.

[error in script]

IITH Creators: