Synthesis of 2,3-Biaryl Epoxy Indanone and One-pot Synthesis of α-Acyloin Indanone

Negi, Rollania and Khan, Faiz Ahmed (2018) Synthesis of 2,3-Biaryl Epoxy Indanone and One-pot Synthesis of α-Acyloin Indanone. Masters thesis, Indian Institute of Technology, Hyderabad.

Text Thesis_Msc_CY_3930.pdf - Submitted Version Restricted to Repository staff only until June 2020. Download (3MB) | Request a copy

Abstract

Base and solvent controlled synthesis of biologically active epoxy indanone and one pot α- hydroxy indanone (α-acyloin) from 2,3-diaryl dihydro indanone and 2,3-diaryl indenone, respectively was reported here. This reaction proceeds via a dianion intermediate in presence of base with oxygen bubbling leading to epoxy indanone and further hydrolysis leading to hydroxyl indanone. One-pot synthesis protocol was achieved directly from biaryl indenone followed by reduction, epimerization and oxygen trapping. This serendipitous formation of epoxy indanone from reduced diaryl dihydro indanone is eccentric and lucid and occurs within a short span of time

[error in script]

IITH Creators:	IITH Creators ORCiD Khan, Faiz Ahmed UNSPECIFIED
Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Epoxy, Indnone, One-Pot
Subjects:	Chemistry
Divisions:	Department of Chemistry
Depositing User:	Team Library
Date Deposited:	16 May 2018 11:00
Last Modified:	16 May 2018 11:00
URI:	http://raiithold.iith.ac.in/id/eprint/3930
Publisher URL:
Related URLs:	Google Scholar

Actions (login required)

View Item

Statistics for this ePrint Item