Palladium-Catalyzed Copper-Free Sonogashira Coupling of 2-Bromoarylcarbonyls: Synthesis of Isobenzofurans via One-Pot Reductive Cyclization

G, Satyanarayana and Alavala, G K R (2017) Palladium-Catalyzed Copper-Free Sonogashira Coupling of 2-Bromoarylcarbonyls: Synthesis of Isobenzofurans via One-Pot Reductive Cyclization. Synthesis. ISSN 0039-7881 (In Press)

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Abstract

Palladium-catalyzed copper-free Sonogashira coupling of 2-bromocarbonyls is presented. This method afforded the 2-alkynylaryl carbonyls, useful synthons for the accomplishment of many carbocyclic and heterocyclic motifs. Significantly, the strategy was extended to the one-pot synthesis of isobenzofurans via reduction followed by intramolecular 5- exo -dig cyclization.

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IITH Creators:
IITH CreatorsORCiD
G, SatyanarayanaUNSPECIFIED
Item Type: Article
Uncontrolled Keywords: alkynes; benzoxocines; carbonyls; isobenzofurans; Sonogashira coupling
Subjects: Chemistry
Divisions: Department of Chemistry
Depositing User: Team Library
Date Deposited: 28 Aug 2017 05:19
Last Modified: 28 Aug 2017 05:19
URI: http://raiithold.iith.ac.in/id/eprint/3504
Publisher URL: https://doi.org/10.1055/s-0036-1588513
OA policy: http://www.sherpa.ac.uk/romeo/issn/0039-7881/
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