Computational tools to model and analyze biomolecular structures and interactions

L, Ponoop Prasad Patro (2016) Computational tools to model and analyze biomolecular structures and interactions. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Development of the interdisciplinary branch, bioinformatics, is a blessing for life science research. It made the analysis, model, pattern recognition a nd visualization of biological data much easier, efficient and accessible. Now the research in life science is much stronger with efficient outcomes in a shorter period with minimized error, cost and labor. The bioinformatics tools have helped us in better understanding of a process or pathway with aiding us to analyze them with our convenience. In my thesis work I have worked on three fields, modelling of 3 dimensional nucleic acid structures, finding the steric hindrance in molecules and identifying the a mino acids surrounding the sugar ligand in a catalytic pocket to identify catalysis sites in the protein as they are highly conserved invariant of the source organism. The nucleic acid models generated through our server can be utilized as starting model f or different research purposes related to nucleic acids and interactions associated to them. Steric hindrance identifier will help in validating models and the identified conserved aminoacids will further be used in automated identification of catalytic si tes in glycosidases and can also be useful in explaining the cause specificity and selectivity of the proteins towards a specific sugar moiety

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IITH Creators:
IITH CreatorsORCiD
Item Type: Thesis (Masters)
Uncontrolled Keywords: Bioinformatics tools, nucleic acids, glycosidases, server steric hindrance, TD647
Subjects: Others > Biotechnology
Divisions: Department of Biotechnology
Depositing User: Team Library
Date Deposited: 15 Sep 2016 06:12
Last Modified: 30 Jul 2019 07:29
URI: http://raiithold.iith.ac.in/id/eprint/2756
Publisher URL:
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