Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers

Durga Prakash, M and Vanjari, Siva Rama Krishna and Sharma, Chandra Shekhar and Singh, Shiv Govind (2016) Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers. Sensors, 16 (9). p. 1354. ISSN 1424-8220

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Abstract

This paper reports the synthesis and fabrication of aligned electrospun nanofibers derived out of multiwalled carbon nanotubes (MWCNTs) embedded SU-8 photoresist, which are targeted towards ultrasensitive biosensor applications. The ultrasensitivity (detection in the range of fg/mL) and the specificity of these biosensors were achieved by complementing the inherent advantages of MWCNTs such as high surface to volume ratio and excellent electrical and transduction properties with the ease of surface functionalization of SU-8. The electrospinning process was optimized to precisely align nanofibers in between two electrodes of a copper microelectrode array. MWCNTs not only enhance the conductivity of SU-8 nanofibers but also act as transduction elements. In this paper, MWCNTs were embedded way beyond the percolation threshold and the optimum percentage loading of MWCNTs for maximizing the conductivity of nanofibers was figured out experimentally. As a proof of concept, the detection of myoglobin, an important biomarker for on-set of Acute Myocardial Infection (AMI) has been demonstrated by functionalizing the nanofibers with anti-myoglobin antibodies and carrying out detection using a chemiresistive method. This simple and robust device yielded a detection limit of 6 fg/mL.

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IITH Creators:

IITH Creators	ORCiD
Vanjari, Siva Rama Krishna	UNSPECIFIED
Sharma, Chandra Shekhar	https://orcid.org/0000-0003-3821-1471
Singh, Shiv Govind	http://orcid.org/0000-0001-7319-879X

Item Type:

Article

Uncontrolled Keywords:

ultra sensitivity; nanobiosensors; electrospinning; MWCNTs; SU-8; chemiresistive

Subjects:

Others > Electricity
Chemical Engineering > Biochemical Engineering

Divisions:

Department of Chemical Engineering
Department of Electrical Engineering

Depositing User:

Team Library

Date Deposited:

08 Sep 2016 09:45