Development of Computational Model of Spinal Cord Neural Circuit In Neuroconstruct Modelling Platform and Rendering of the Spinal Cord Model and Modelling of Synapses and Cell Types

Sarkar, Anindya (2016) Development of Computational Model of Spinal Cord Neural Circuit In Neuroconstruct Modelling Platform and Rendering of the Spinal Cord Model and Modelling of Synapses and Cell Types. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

The explosive growth in imaging technologies has been matched by an extraordinary increase in the number of investigations focusing on the structural and functional organization of the human spinal cord. The construction of comprehensive spinal cord atlases and databases of 3-dimensional spinal cord maps are very helpful in the field of neurological treatment and surgical analytics. Some of the notable ones among these Atlases are MRI Based Atlases,Cryoimaging Atlases,Multi-modality Atlases etc. But these Atlases are passive images that show the distribution of different anatomical or functional aspects. We aim to build a neurophysiology simulator of the relevant circuits in 3D anatomical coordinates that embody the biophysical knowledge. After superimposing this simulator on available Atlases or functional imagery like MRI.A clinician can ask questions on the functional implication of a procedure or the potential etiologies for a manifest condition. Further a systems analysis of the connectivities can provide clues to identification of network motifs responsible for oscillations and pattern generators. Towards this end we are making a realistic 3 dimensional model of a human spinal cord using NeuroConstruct and NEURON Simulation environment. The construction of such a 3D model involves identification of neuron biophysics, connectivities,cell types,synaptic Mechanisms, Channel Mechanisms,Morphology, Dendritic Architectures,locations.

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