R, Aishwarya
(2016)
Lab on chip device for separation of Plasma from Blood.
Masters thesis, Indian Institute of Technology Hyderabad.
Abstract
Microfluidics has developed as a set of powerful tools that have greatly advanced in some areas of biological research. The use of microfluidics has enabled many experiments that are otherwise impossible with conventional methods and is highly capable of providing advantages in terms of a significant reduction in the sample processing time, sample volumes, and consumption of costly reagents. Various research groups have established continuous flow separation methods in microfluidic devices; however, they have worked with relatively small dimension Micro channels (similar to the blood cell diameter). The present work demonstrates separation of plasma by utilizing the hydrodynamic separation techniques in micro channels with size of the order of mm. The separation process exploits the phenomenon, which is very similar to that of plasma skimming explained under Zweifach-Fung bifurcation law. The T microchannel device (comprising perpendicularly connected blood and plasma channels) were micro-fabricated using su8 negative photo resist and for calculating the efficiency of the device electrodes were deposited
on both the substrates.
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