Comparison of H2O diffusion mechanism of Klebsiella pneumonia outer membrane lectin with its E. coli counterpart

Sachdeva, Shivangi (2016) Comparison of H2O diffusion mechanism of Klebsiella pneumonia outer membrane lectin with its E. coli counterpart. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Emergence of multi drug resistant bacteria is a major cause of infections worldwide. In Gram-negative bacteria, pathogenicity is mainly due to bacterial toxins, cell surface proteins, cell surface polysaccharides and hydrolytic enzymes. Different types of surface polysaccharides are lipopolysaccharide, capsular polysaccharide and exopolysaccharides. The mechanism behind capsular polysaccharide (CPS) translocation to the exterior of bacterium and its association with outer membrane is unknown. Inhibition of CPS biogenesis or exportation to the outer membrane may be an attractive strategy to reduce bacterial virulence. Anchoring of CPS to the outer membrane is done via Wzi,an outer membrane protein. This protein plays dual role as a lectin and porin. This study focuses on understanding water diffusion mechanisms of Wzi through molecular dynamics simulations.

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