Hyperv Alent Iodine Mediated Oxidative Annulations and cross Dehydrogenative Couplings

Muni, Sitansu and D S, Sharada (2016) Hyperv Alent Iodine Mediated Oxidative Annulations and cross Dehydrogenative Couplings. Masters thesis, Indian Institute of Technology Hyderabad.

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Abstract

Iodine is a special element. Its speciality lies in the fact that it is the heaviest non radioactive element in the periodic table and it is the most polarizable of the halogens. Amongst many iodine compounds that we have observed hypervalent(polyvalent )iodine compounds are the best. The time from 1990 onwards has seen a streak advancement of the applications of Hypervalent Iodine in organic synthesis. Hypervalent iodine compounds have received considerable attention these years because of their non toxic ,recyclable, oxidizing, electrophilic characteristics. Hypervalent Iodine compounds are not only used as SET reagents but also they are used in delivery of many functional groups. They are also used in Azidation ,Aminations, Radical fragmentations ,Oxidative Coupling of aromatic substrates, Oxidation of alkenes and alkynes, Thiocyanations, Arylselenations. Poly Iodide compounds are also used for facile and efficient oxidation of primary alcohols to aldehydes and secondary alcohols to ketones. PhIO2 can generate the alkoxy radicals from alcohols in certain photochemical reactions. Hypervalent iodine reagents are also used as polymerization initiators(ex Diaryl iodonium salts). There are many hypervalent iodine reagents. To name a few we have PIDA, PIFA ,IBX,DMP etc. Chemists have successfully conducted the reactions of hypervalent iodine in water,recyclable organic solvents, and also in solvent free conditions. Several reviews and books have been published regarding hypervalent iodine which have described its chararcteristics .We have compiled authentic information from 2009-2016 regarding application of hypervalent iodine.

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